LIMITED EDITION EXCLUSIVE LSD CRYSTAL) NO FURTHER A MYSTERY

In the LSD-bound crystal structure, the aspect chain of your lid residue L209EL2 varieties in depth hydrophobic contacts with both LSD and surrounding residues in TMs III, IV, and V (Determine 4C). When the lid moved aside to reveal the binding pocket in simulation, many of these contacts broke. We thus hypothesized that L209EL2 functions as being